Heavy rainfall at the end of December, the worst since May 2011, caused the Mississippi, Meramec, and Missouri rivers to burst their banks.
The Mississippi River was 40 feet (13 meters) over the flood mark at one stage, while 17 million people faced imminent danger.
US President Barack Obama signed an emergency declaration, allowing federal aid to be used in the clean-up operations.
Visiting the affected-communities of Eureka and Cape Girardeau on Sunday, Missouri governor Jay Nixon described the damage as “almost as if you are living on some other planet.”
Cape Girardeau resident Oral R Friend captured footage of some of the devastation from the air with a drone.
The strangely-serene clips of the mighty Miss show marooned homes in what look like scenes from a Hollywood disaster movie.
“Cloudy, cold and the waters are rising,” Friend posted on Facebook. “I put it together rather quickly, but it should help give a view of some of the areas around Cape that are feeling the effects of the water.”